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Signoret-Genest, J., Schukraft, N. and Tovote, P. (2024). Measuring Heart Rate in Freely Moving Mice. Bio-protocol 14(3): e4926. DOI: 10.21769/BioProtoc.4926


Rodriguez-Rozada S, Frantz S, Tovote P. Cardiac optogenetics: regulating brain states via the heart. Signal Transduct Target Ther. 2023 Aug 30;8(1):324. doi: 10.1038/s41392-023-01582-6. PMID: 37644039; PMCID: PMC10465583

Lantheaume A, Schöneberg N, Rodriguez-Rozada S, Doll D, Schellenberger M, Kobel K, Katzenberger K, Signoret-Genest J, Tissone AI, Ip CW, Esposito MS, Tovote P. A viral vector model for circuit-specific synucleinopathy. Biorxiv. 2023 Aug 29. doi:

da Silva GN, Seiffert N, Tovote P. Cerebellar contribution to the regulation of defensive states. Front Syst Neurosci. 2023 Mar 31;17:1160083. doi: 10.3389/fnsys.2023.1160083. PMID: 37064160; PMCID: PMC10102664.

Griebel M, Segebarth D, Stein N, Schukraft N, Tovote P, Blum R, Flath CM. Deep learning-enabled segmentation of ambiguous bioimages with deepflash2. Nat Commun. 2023 Mar 27;14(1):1679. doi: 10.1038/s41467-023-36960-9. PMID: 36973256; PMCID: PMC10043282.

Signoret-Genest J, Schukraft N, L Reis S, Segebarth D, Deisseroth K, Tovote P. Integrated cardio-behavioral responses to threat define defensive states. Nat Neurosci. 2023 Mar;26(3):447-457. doi: 10.1038/s41593-022-01252-w. Epub 2023 Feb 9. PMID: 36759559; PMCID: PMC9991919.


Merscher AS, Tovote P, Pauli P, Gamer M. Centralized gaze as an adaptive component of defensive states in humans. Proc Biol Sci. 2022 May 25;289(1975):20220405. doi: 10.1098/rspb.2022.0405. Epub 2022 May 18. PMID: 35582796; PMCID: PMC9114933.

Khayenko V, Schulte C, Reis SL, Avraham O, Schietroma C, Worschech R, Nordblom NF, Kachler S, Villmann C, Heinze KG, Schlosser A, Schueler-Furman O, Tovote P, Specht CG, Maric HM. A Versatile Synthetic Affinity Probe Reveals Inhibitory Synapse Ultrastructure and Brain Connectivity. Angew Chem Int Ed Engl. 2022 Jul 25;61(30):e202202078. doi: 10.1002/anie.202202078. Epub 2022 May 6. PMID: 35421279; PMCID: PMC9400903.

Wenger N, Vogt A, Skrobot M, Garulli EL, Kabaoglu B, Salchow-Hömmen C, Schauer T, Kroneberg D, Schuhmann MK, Ip CW, Harms C, Endres M, Isaias IU, Tovote P, Blum R. Rodent models for gait network disorders in Parkinson's disease - a translational perspective. Exp Neurol. 2022 Jun;352:114011. doi: 10.1016/j.expneurol.2022.114011. Epub 2022 Feb 14. PMID: 35176273.

Peng Y, Schöneberg N, Esposito MS, Geiger JRP, Sharott A, Tovote P. Current approaches to characterize micro- and macroscale circuit mechanisms of Parkinson's disease in rodent models. Exp Neurol. 2022 May;351:114008. doi: 10.1016/j.expneurol.2022.114008 . Epub 2022 Feb 9. PMID: 35149118 ; PMCID: PMC7612860.


Pernía-Andrade A, Wenger N, Esposito M and Tovote P. Circuits for State-Dependent Modulation of Locomotion. Frontiers in Human Neuroscience. 2021 Nov 10; 10.3389/fnhum.2021.745689

Whittle N, Fadok J, MacPherson K, Nguyen R, Botta P, Wolff SBE, Müller C, Herry C, Tovote P, Holmes A, Singewald N, Luthi A,  Ciocchi S. Central amygdala micro-circuits mediate fear extinction. Nature communications. 2021 Jul 06; 10.1038/s41467-021-24068-x

Knorr S, Rauschenberger L, Pasos UR, Friedrich MU, Peach RL, Grundmann-Hauser K, Ott T, O'Leary A, Reif A, Tovote P, Volkmann J, Ip CW. The evolution of dystonia-like movements in TOR1A rats after transient nerve injury is accompanied by dopaminergic dysregulation and abnormal oscillatory activity of a central motor network. Neurobiol Dis. 2021 Mar 19;154


Schaefer N, Signoret-Genest J, R. von Collenberg R, Wachter B, Deckert J, Tovote P, Blum R, Villmann C. Anxiety and Startle Phenotypes in Glrb Spastic and Glra1 Spasmodic Mouse Mutants. Front Mol Neurosci. 2020 Aug 13

Andreska T, Rauskolb S, Schukraft N, Lüningschrör P, Sasi M, Signoret-Genest J, Behringer M, Blum R, Sauer M, Tovote P, Sendtner M. Induction of BDNF Expression in Layer II/III and Layer V Neurons of the Motor Cortex Is Essential for Motor Learning. J Neurosci. 2020 Aug 12;40(33):6289-6308.


Striatal dopaminergic dysregulation and dystonia-like movements induced by sensorimotor stress in a pharmacological mouse model of rapid-onset dystonia-parkinsonism. Rauschenberger L, Knorr S, Al-Zuraiqi Y, Tovote P, Volkmann J, Ip CW. Experimental Neurology 323:113109, 2019.


A critical role for neocortical processing of threat memory. Dalmay T*, Abs E*, Poorthuis RB, Hartung J, Pu D, Onasch S, Lozano Y, Signoret-Genest J, Tovote P, Gjorgjieva J, Letzkus JJ. Neuron 104(6):1180-1194, 2019.


New perspectives on central amygdala function. Fadok JP, Markovic M, Tovote P, Lüthi A.

Current Opinion in Neurobiology 49:141-147, 2018.



A competitive inhibitory circuit for selection of active and passive fear responses. Fadok JP, Krabbe S, Markovic M, Courtin J, Xu C, Massi L, Botta P, Bylund K, Müller C, Kovacevic A, Tovote P, Lüthi A. Nature 542(7639): 96-100, 2017.



Midbrain circuits for defensive behavior. Tovote P*#, Esposito* MS, Botta P, Chaudun F, Fadok JP, Markovic M, Wolff SBE, Ramakrishnan C, Fenno, L., Deisseroth K, Herry C, Arber S, Lüthi A#. Nature 534(7606): 206-212, 2016.


Neuronal circuits for fear and anxiety. Tovote P*, Fadok JP*, Lüthi A#. Nature Reviews Neuroscience 16(6):317-31, 2015.


Amygdala interneuron subtypes control fear learning through disinhibition. Wolff SBE*, Gründemann J*, Tovote P, Krabbe S, Jacobson GA, Müller C, Herry C, Ehrlich I, Friedrich RW, Letzkus JJ, Lüthi A#. Nature 509(7501):453-8, 2014.


A disinhibitory microcircuit for associative fear learning in the auditory cortex. Letzkus JJ*#, Wolff SBE*, Meyer EMM, Tovote P, Courtin J, Herry C, Lüthi A#. Nature 480(7377):331-5, 2011.



Maternal Separation Modulates Short Term Behavioral and Physiological Indices of the Stress Response. Litvin Y, Tovote P, Pentkowski N, Zeyda T, King LB, Vasconcellos AJ, Dunlap CC, Spiess J, Blanchard DC, Blanchard RJ#. Hormones & Behavior 58(2):241-249, 2010.

Activation of central CRF receptor 1 by cortagine results in enhanced passive coping with a naturalistic threat in mice. Tovote P, Borna Farrokhi C, Gonzales RMK, Schnitzbauer U, Blanchard DC, Blanchard RJ, Spiess J#. Psychoneuroendocrinology, 35(6):887-895, 2010.




Heart rate dynamics and behavioral responses during acute emotional challenge in corticotropin-releasing factor receptor 1-deficient and corticotropin-releasing factor-overexpressing mice. Tovote P, Meyer M, Ronnenberg A, Ögren SO, Spiess J, Stiedl O#. Neuroscience, 134(4):1113-22, 2005.

Dissociation of temporal dynamics of heart rate and blood pressure responses elicited by conditioned fear but not acoustic startle. Tovote P, Meyer M, Pilz PK, Ronnenberg A, Ögren SO, Spiess J, Stiedl O#. Behavioral Neuroscience, 119(1):55-65, 2005.

Time-dependent involvement of the dorsal hippocampus in trace fear conditioning in mice. Misane I, Tovote P, Meyer M, Spiess J, Ögren SO, Stiedl O#. Hippocampus, 15(4):418-26, 2005.


Central NPY receptor-mediated alteration of heart rate dynamics in mice during expression of fear conditioned to an auditory cue. Tovote P, Meyer M, Beck-Sickinger AG, von Horsten S, Ögren SO, Spiess J, Stiedl O#. Regulatory Peptides, 120(1-3):205-14, 2004.


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